Research Methods

Animal Behavioral Models of Schizophrenia

Models of Positive Symptoms of Schizophrenia:

  • Amphetamine-induced hyperlocomotion
  • PCP-induced hyperlocomotion
  • Conditioned avoidance response 
  • Prepulse inhibition of acoustic startle reflex 
  • Latent inhibition

Models of Negative Symptoms of Schizophrenia:

  • Social withdrawal in rodent social interaction

Models of Cognitive Dysfunctions of Schizophrenia:

  • Social working memory

Animal Models of Fear/Anxiety, Depression and PTSD

  • Learned helplessness
  • Elevated Plus Maze 
  • Forced swim test 
  • Conditioned avoidance response with multiple measures of fear responses (body temperature, defecation, ultrasonic vocalizations, etc.)

Animal Models of Drug Abuse on Affects

  • Ultrasonic vocalizations (22 kHz and 50 kHz) 
  • Locomotor activity 

Brain Techniques

  • Immunocytochemistry
  • Central microinfusion of drugs
  • Electrolytic and neurotoxic lesions

Click on  to view a PDF version of the Standard Operating Procedure for the equipment.